Ads：课题组每年招收化学相关专业的硕士生和博士生（含硕博连读）。此外，招聘具有催化化学、物理化学、有机化学或者化学生物学背景的教职工。
一、教育和工作经历
2021-至今 威廉希尔体育app官网 教授（破格）
2017-2020 威廉希尔体育app官网 副研究员/副教授
2015-2017 德国康斯坦茨大学 博士后 合作导师：Prof. Jörg S. Hartig
2013-2015 美国马里兰大学帕克分校 博士后 合作导师：Prof. Herman O. Sintim
2006-2013 中国科学院大连化学物理研究所 博士 导师：李灿 院士
2002-2006 williamhill威廉希尔官网化学与材料科学学院 学士
二、研究兴趣
（1）研究环二核苷酸、G-四链体、i-motif等新型核酸的化学生物学功能，特别是其空间构型和其催化性能之间的构效关系。旨在通过研究核酸的催化性能，揭示核酸在自然界中潜在的新功能。
（2）研究仿生体系、生物医用材料等的表界面化学行为，特别是催化性能和应用功能。旨在通过研究上述体系，开发简单、实用、高效、功能性的仿生/医用材料，促进产学研的良性发展。
三、学生培养
(1)在读研究生
董星辰 杨礼冰 张卓琳 王梓潇 秦玮骏
22级博士生 20级硕士生 20级硕士生 21级硕士生 21级硕士生
西安建筑科技大学 内蒙古大学 williamhill威廉希尔官网 东北师范大学 忻州师范学院
xingchen@snnu.edu.cn lbyang@snnu.edu.cn zhuolinzhang@snnu.edu.cn zxwang@snnu.edu.cn weijunqin@snnu.edu.cn
刘莉 刘伟 周家俊 赵志昊 徐海鹏
21级硕士生 21级硕士生 22级硕士生 22级硕士生 22级硕士生
青海大学 williamhill威廉希尔官网 重庆师范大学 南京理工大学 武汉大学
liliu@snnu.edu.cn qq1328135359@snnu.edu.cn jjzhou@snnu.edu.cn zhzhao@snnu.edu.cn hpxu@snnu.edu.cn
(2)已毕业的研究生
郝 敏 2016-2019 工学硕士 环二核苷酸人工金属酶催化的不对称Friedel-Crafts反应研究
齐倩倩 2017-2020 理学硕士 基于c-di-AMP和ATP组装人工核酸金属酶及其手性催化功能研究
董星辰 2018-2021 理学硕士 核苷酸杂化催化剂主客体组装模式及其不对称催化性能研究
吕舒婷 2018-2021 理学硕士 环二鸟苷酸的催化氧性能及其与金属辅因子的协同催化效应
顾由琨 2019-2022 理学硕士 二核苷酸杂化催化剂的类氧化酶活性与光调控不对称催化性能研究
邬佩哲 2019-2022 理学硕士 i-motif DNA杂化催剂构筑及其不对称催化性能研究
张文阅 2019-2022 理学硕士 基于ATP和FAD核苷酸杂化催化剂构筑及其不对称催化性能研究
张卓琳 2020-2023 理学硕士 金属离子介导的i-motif DNA杂化催化剂不对称催化性能研究
杨礼冰 2020-2023 理学硕士 核苷酸杂化催化剂对逆电子需求杂Diels-Alder反应的不对称催化性能研究
(3)参与大学生创新创业项目的本科生
2023年大学生创新创业项目：王紫榛、张瑾、杨瑞欣、赵鑫
2022年大学生创新创业项目-国家级：钱浩玮、郭珂怡、王源钰、谢欣怡
2021年大学生创新创业项目-省级：李嘉琦、龙亚洁、安雨桐、卫郑伟
2019年大学生创新创业项目-国家级重点：伍文婧、董春博、任雨欣、张文舒、程庆雯
2018年大学生创新创业项目-国家级重点：袁梓健、曲瑶、裴雪、高雨欣
(4)在本组完成学位论文的本科生
2023届：李嘉琦、龙亚洁
2022届：任阳、胡瑞洋、苏贵楠
2021届：刘伟、任雨欣、程庆雯
2020届：曲瑶、高雨欣
2019届：李静、裴玉娟
2018届：熊令、高换换
四、学术/教学奖励
2023年：全国高校青年教师教学竞赛（二等奖）
2023年：陕西高校青年教师教学竞赛（特等奖）
2022年：国家优秀青年基金获得者
2022年：williamhill威廉希尔官网教学质量奖
2021年：williamhill威廉希尔官网课堂教学创新大赛（一等奖）
2019年：williamhill威廉希尔官网青年教师教学大赛（二等奖）
2013年：中国科学院院长奖（优秀奖）
2012年：林励吾催化奖（优秀博士生奖）
五、承担科研项目情况
[8] 国家自然科学基金-优青项目, “核酸催化化学”, 22222203, 2023.01-2025.12.
[7] 国家自然科学基金-面上项目, “环状RNA人工金属酶主客体相互作用及手性催化构效关系”, 22072080, 2021.01-2024.12.
[6]中央高校基金自由探索-重点项目, “人工金属核酸酶的精准构建及其手性催化性能”, GK202102002, 2021.01-2023.12.
[5] 威廉希尔体育app官网-腾飞计划学者项目, “人工核酸酶的催化性能研究”, 2021.01-2023.12.
[4] 陕西省自然科学基金-青年项目, “CDN人工金属酶的组装及其手性催化功能研究”, 2019JQ161, 2019.01-2020.12.
[3] 留学人员科技活动择优支持项目-优秀类, “环二核苷酸的催化功能研究”, 2018008, 2018.10-2020.09.
[2] 中央高校基金自由探索-重点项目, “环二核苷酸的手性催化功能研究”, GK201802001, 2018.01-2020.12.
[1] 国家自然科学基金-青年项目, “环二鸟苷酸的手性催化功能研究”, 21703132, 2018.01-2020.12.
六、承担教学情况
本科生课程：《物理化学》、《基础物理化学实验》、《物理化学研究进展和前瞻》、《化学：中心科学》
研究生课程：《科技论文写作》（全英）
七、论文列表
[36]Nini Li, Xiaohong Ji, Somnath Mukherjee, Bing Yang, Yuqing Ren,Changhao Wang* and Yashao Chen*, A bioinspired skin UV filter with broadband UV protection, photostability, and resistance to oxidative damage. ACS Appl. Mater. Interfaces,2023,15, 10383-10397.
[35] Xingchen Dong, Shuting Lv, Qianqian Qi, Youkun Gu, Peizhe Wu, Wenyue Zhang, Zhuolin Zhang, Libing Yang, Jiaqi Li, Yashao Chen and Changhao Wang*, Cyclic dinucleotide-based enantioselective fluorination in water. J. Org. Chem., 2023, 88, 189-197.
[34] Liu Jiang, Niuniu Qin, Shunli Gu, Wancheng Zhu, Changhao Wang* and Yashao Chen*, Rational design of dual-functional surfaces on polypropylene with antifouling and antibacterial performances via a micropatterning strategy. J. Mater. Chem. B, 2022, 10, 3759-3769.
[33] Shan Zhang, Ruiqi Liang, Kun Xu, Shurong Zheng, Somnath Mukherjee, Peng Liu*,Changhao Wang*and Yashao Chen*, Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application.Mater. Sci. Eng. C,2022,132, 112636.
[32] Xingchen Dong,# Zijian Yuan,# Yao Qu, Yuxin Gao, Xue Pei, Qianqian Qi, Yujuan Pei, Jiaqi Li, Yashao Chen and Changhao Wang*, An ATP–Cu(II) catalyst efficiently catalyzes enantioselective Michael reactions in water. Green Chem., 2021, 23, 9876-9880. (# equal author)
[31] Nini Li, Xiaohong Ji, Bulei Wang, Yanglin Guo,Changhao Wang*and Yashao Chen*, Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.Mater. Sci. Eng. C,2021,128, 112346.
[30] Nini Li,#Le Yun,#Xiaohong Ji, Somnath Mukherjee,Changhao Wang*and Yashao Chen*, Construction of photoresponsive azobenzene-decorated cationic surfactant-based self-assembled vesicles and controlled drug release.Colloids Surf. A.,2021,631, 127711. (# equal author)
[29] Changhao Wang,#,* Qianqian Qi,# Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen and Jörg S. Hartig, A Cu(II)-ATP complex efficiently catalyses enantioselective Diels-Alder reactions. Nat. Commun., 2020, 11, 4792. (# equal author)
[28]Changhao Wang,#,*Min Hao,#Qianqian Qi,Jingshuang Dang, Xingchen Dong, Shuting Lv, Ling Xiong, Huanhuan Gao, Guoqing Jia, Yashao Chen*, Jörg S. Hartig and Can Li, Highly efficient cyclic dinucleotide based artificial metalloribozymes for enantioselective Friedel-Crafts reactions in water.Angew. Chem. Int. Ed.,2020,59, 3444-3449.(# equal author)
[27]Jing Zhang,#Nini Li,#Dongmei Zhang, Mengjin Dong,Changhao Wang*and Yashao Chen*, Construction of cinnamic acids derived β-cyclodextrins and their emodin-based inclusions with enhanced water solubility, excellent antioxidant and antibacterial activities,Colloids Surf. A., 2020,606, 125382. (# equal author)
[26] Qianqian Qi, Shuting Lv, Min Hao, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen* andChanghao Wang*, An efficient cyclic di-AMP based artificial metalloribozyme for enantioselective Diels-Alder reactions.Eur. J. Org. Chem.,2020,2020, 4417-4424.
[25] Hongkai Wang,#Weihuang Zhu,#Qi Xue,Changhao Wang*and Kaiqiang Liu*, Solvent dispersion triggered the formation of NiFe-gel as an efficient electrocatalyst for enhancing the oxygen evolution reaction.Chem. Commun.,2020,56, 7781-7784. (# equal author)
[24] Wancheng Zhu, Liu Jiang, Bulei Wang, Shunli Gu, Fenyan Hu,Changhao Wang*and Yashao Chen*, Rational design of PMPC/PDMC/PEGDA hydrogel micropatterns onto polylactic acid with enhanced biological activity.ACS Biomater. Sci. Eng.,2020,6, 3799-3810.
[23] Dongmei Zhang, Guanke Cai, Somnath Mukherjee, Yajuan Sun,Changhao Wang, Bingjie Mai, Kaiqiang Liu, Cheng Yang* and Yashao Chen*, Elastic, persistently moisture-retentive, and wearable biomimetic film inspired by fetal scarless repair for promoting skin wound healing,ACS Appl. Mater. Interfaces,2020,12, 5542-5556.
[22] Dongmei Zhang, Bulei Wang, Yajuan Sun,Changhao Wang, Somnath Mukherjee, Cheng Yang* and Yashao Chen*, Injectable enzyme-based hydrogel matrix with precisely oxidative stress defense for promoting dermal repair of burn wound,Macromol. Biosci.,2020,20, 2000036.
[21] Minting Du,#Mengke Peng,#Bingjie Mai, Fenyan Hu, Xiaodan Zhang, Yashao Chen* andChanghao Wang*, A multifunctional hybrid inorganic-organic coating fabricated on magnesium alloy surface with antiplatelet adhesion and antibacterial activities,Surf. Coat. Tech.,2020,384, 125336. (# equal author)
[20]Mengke Peng, Fenyan Hu, Minting Du, Bingjie Mai, Shurong Zheng, Peng Liu,Changhao Wang*and Yashao Chen*, Hydrothermal growth of hydroxyapatite and ZnO bilayered nanoarrays on magnesium alloy surface with antibacterial activities,Front. Mater. Sci.,2020,14, 14-23.
[19]Changhao Wang*, Min Hao, Qianqian Qi, Yashao Chen and Jörg S. Hartig*, Chemical synthesis, purification, and characterization of 3’-5’-linked canonical cyclic dinucleotides (CDNs).Method Enzymol.,2019,625, 41-59.
[18] Liu Jiang, Wancheng Zhu, Huaming Qian,Changhao Wang*, Yashao Chen* and Peng Liu*, Fabrication of PMPC/PTM/PEGDA micropatterns onto polypropylene films behaving with dual functions of antifouling and antimicrobial activities.J. Mater. Chem. B,2019,7, 5078-5088.
[17] Mengke Peng, Xiaodan Zhang, Xiao Xiao, Mengjin Dong, Guowei Zhao, Peng Liu, Yashao Chen* andChanghao Wang*, Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities.J. Coat. Technol. Res.,2019,16, 857-868.
[16]Sebastian Knorr,#Malte Sinn,#Dmitry Galetskiy, Rhys M. Williams,Changhao Wang, Nicolai Müller, Olga Mayans, David Schleheck and Jörg S. Hartig*, Widespread bacterial lysine degradation proceeding via glutarate andL-2-hydroxyglutarate.Nat. Commun.,2018,9,5071. (# equal author)
[15]Dongmei Zhang, Cheng Yang*, Ziru Niu,Changhao Wang, Somnath Mukherjee, Dan Wang, Xi Li, Ruiqi Liu, Jin Gao and Yashao Chen*, Construction of crowningβ-cyclodextrin with temperature response and efficient properties of host–guest inclusion.Langmuir,2018,34, 11567-11574.
[14]Jie Yang, Le Yun, Guowei Zhao, Feng Zhang, Yashao Chen* andChanghao Wang*, Fabrication of pH-responsive system based on cationic gemini surfactant/sodium octanedioate and its application on controlled release of paclitaxel.Colloids Surf. A., 2018,539, 101-108.
[13]Changhao Wang, Malte Sinn, Julia Stifel, Anna C. Heiler, Annette Sommershof and Jörg S. Hartig*, Synthesis of all possible canonical (3´-5´-linked) cyclic dinucleotides and evaluation of riboswitch interactions and immune-stimulatory effects.J. Am. Chem. Soc.,2017,139, 16154-16160.
[12] Xiaochu Ma,#Jie Zhou,#Changhao Wang,# Brandon Carter-Cooper, Fan Yang, Elizabeth Larocque, Jonathan Fine, Genichiro Tsuji, Gaurav Chopra, Rena G. Lapidus and Herman O. Sintim*, Identification of new FLT3 inhibitors that potently inhibit AML cell lines, via an azo click-it/staple-it approach.ACS Med. Chem. Lett.,2017,8,492-497.(# equal author)
[11]Changhao Wang, Brandon Carter-Cooper, Yixuan Du, Jie Zhou, Musabbir A. Saeed, Jinbing Liu, Min Guo, Benjamin Roembke, Clinton Mikek, Edwin A. Lewis, Rena G. Lapidus and Herman O. Sintim*, Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.Eur. J. Med. Chem.,2016,118, 266-275.
[10] Yinghao Li,Changhao Wang, Jingya Hao, Mingpan Cheng, Guoqing Jia* and Can Li*, Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels-Alder reaction: An unexpected inversion of enantioselectivity modulated by K+and NH4+ions.Chem. Commun.,2015,51, 13174-13177.
[9] Yinghao Li, Mingpan Cheng, Jingya Hao,Changhao Wang, Guoqing Jia* and Can Li*, Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme.Chem. Sci.,2015,6, 5578-5585.
[8] Yinghao Li,#Guoqing Jia,#Changhao Wang, Mingpan Cheng and Can Li*, Higher-order human telomeric G-quadruplex DNA metalloenzymes enhance enantioselectivity in Diels-Alder reaction.ChemBioChem,2015,16,618-624.(# equal author)
[7]Changhao Wang, Guoqing Jia, Yinghao Li, Sufang Zhang and Can Li*, Na+/K+switch of enantioselectivity in G-quadruplex DNA-based catalysis.Chem. Commun.,2013,49, 11161-11163.
[6]Changhao Wang, Yinghao Li, Guoqing Jia, Shengmei Lu, Yan Liu and Can Li*, DNA catalyzed dithioacetalization in water.Acta Chim. Sinica,2013,71, 36-39.
[5] Yinghao Li,Changhao Wang, Guoqing Jia, Shengmei Lu and Can Li*, Enantioselective Michael addition reactions in water using a DNA-based catalyst.Tetrahedron,2013,69, 6585-6590.
[4]Changhao Wang, Guoqing Jia, Jun Zhou, Yinghao Li, Yan Liu, Shengmei Lu and Can Li*, Enantioselective Diels−Alder reaction with G-quadruplex DNA-based catalysts.Angew. Chem. Int. Ed.,2012,51, 9352-9355.
[3]Changhao Wang, Yinghao Li, Guoqing Jia, Yan Liu, Shengmei Lu and Can Li*, Enantioselective Friedel−Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme.Chem. Commun.,2012,48, 6232-6234.
[2] Shi Qiu,#Guanna Li,#Peng Liu,Changhao Wang, Zhaochi Feng* and Can Li*, Chirality transition in the epoxidation of (-)-α-pinene and successive hydrolysis studied by Raman optical activity and DFT.Phys.Chem.Chem.Phys.,2010,12,3005-3013.(# equal author)
[1] Peng Liu,Changhao Wangand Can Li*, Epoxidation of allylic alcohols on self-assembled polyoxometalates hosted in layered double hydroxides with aqueous H2O2as oxidant.J.Catal.,2009,262, 159-168.
更新于2023年7月
